Scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI have developed a new toothpaste that targets the specific bacteria responsible for gum disease without destroying the mouth's healthy microbial ecosystem.
The innovation uses a compound called guanidinoethylbenzylamino imidazopyridine acetate to block the growth of harmful microbes rather than killing them outright. This approach aims to prevent periodontitis while allowing beneficial bacteria to stabilize the oral environment.
Traditional oral care products, such as alcohol-based mouthwashes, often wipe out both harmful and beneficial microbes. This destruction can lead to dysbiosis, a state where harmful bacteria like Porphyromonas gingivalis quickly recolonize the mouth.
Restoring microbial balance
Stephan Schilling, Head of the Fraunhofer IZI branch for Molecular Drug Biochemistry and Therapy Development, said the substance works in harmony with healthy bacteria. "Rather than simply killing gingivitis pathogens, it inhibits their growth," Schilling said. "They are unable to exert their toxic effects, so beneficial bacteria can occupy niches that would otherwise be inaccessible to them."
The technology has been commercialized by Periotrap Pharmaceuticals GmbH, a spin-off company established in Halle. The company's products are designed to prevent periodontitis while maintaining standard features like fluoride and abrasives for cavity prevention.
Mirko Buchholz, one of the company's founders, noted that the product is specifically designed to support the oral microbiome. The development process involved rigorous testing to ensure the compound does not enter the bloodstream or cause tooth discoloration.
Researchers at the Fraunhofer Institute for Microstructure of Materials and Systems (IMWS) used scanning electron microscopy to evaluate how the toothpaste interacts with teeth and gums. Andreas Kiesow, Group Manager at IMWS, stated that these quantitative measurements allowed the team to determine the substance's compatibility and function.
All testing followed Good Laboratory Practice (GLP) standards to ensure the product meets international quality requirements for medical and cosmetic care.