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02:47 PM UTC · SATURDAY, MAY 2, 2026 LA ERA · Chile
May 2, 2026 · Updated 02:47 PM UTC
Health

Medical experts warn against using diabetes drug metformin for weight loss

Health professionals are alerting the public to the significant health risks, including vitamin B12 deficiency and lactic acidosis, associated with the off-label use of metformin for weight loss.

Lucía Paredes

2 min read

Medical experts warn against using diabetes drug metformin for weight loss
Metformin tablets used for diabetes treatment

Medical specialists are warning against the growing trend of using metformin, a drug prescribed for type 2 diabetes, as an unauthorized weight-loss solution or anti-aging supplement.

According to elmostrador.cl, the misuse of the drug—often promoted on social media as a 'miracle' or 'safe' alternative—poses serious risks to both physical and mental health.

Metformin is primarily used to control blood sugar levels in patients with type 2 diabetes. However, an increasing number of individuals are seeking the drug to achieve rapid weight loss or as a preventative measure against aging.

Carlos Meza, an academic in the Chemistry and Pharmacy program at Universidad Andrés Bello (UNAB), Concepción, stated that the drug's primary indication is the control of hyperglycemia, particularly in patients with insulin resistance.

While Meza noted that the drug has proven efficacy in glycemic control and a favorable safety profile, he also pointed to ongoing studies regarding potential neuroprotective and anti-aging benefits.

Risks of unsupervised use

Despite its clinical benefits, Meza warned that prolonged use without medical supervision can lead to severe side effects.

According to the report by elmostrador.cl, these risks include nausea, vomiting, diarrhea, abdominal pain, and bloating.

More serious complications can arise, such as vitamin B12 deficiency, lactic acidosis, and extreme weight loss or malnutrition.

"Even in older or fragile adults, it can contribute to anorexia, sarcopenia, or unwanted weight loss," Meza warned.

Meza also highlighted that while metformin is an effective and cost-efficient drug, its benefits depend entirely on proper prescription and monitoring. He noted that common clinical errors include starting with high doses without gradual adjustment and failing to monitor B12 levels during long-term treatments.

He specifically cautioned against using the medication as a 'supplement' or for 'preventing diseases' in healthy individuals.

Experts emphasize that no medication should be used as a quick fix for weight loss without professional medical oversight. The rise in off-label use underscores a critical need for better health education to prevent nutritional, metabolic, and psychological damage.

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